产品货号：
Z32185
中文名称：
Caspase 8/CASP8抗体(C-term)
英文名称：
Anti-Caspase 8/CASP8 Antibody(C-term)(Clone#550CT8.5.2)
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Caspase 8/CASP8 Antibody (C-term) (Clone#550CT8.5.2) |
| 指标别名 | Apoptotic protease Mch 5;Casp 8;CASP8;Caspase 8;Caspase 8/p18;Caspase 8/p43/p18;caspase8;FADD like ICE;FLICE;ICE like apoptotic protease 5;MCH5 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB,FCM |
| 基因名称 | CASP8 |
| 克隆号 | 550CT8.5.2 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG1 |
| 免疫原 | This CASP8 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 427-461 amino acids from the C-terminal region of human CASP8. |
| 计算分子量 | 55kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death.Binding to the adapter molecule FADD recruits it to either receptor.The resulting aggregate called death- inducing signaling complex (DISC) performs CASP8 proteolytic activation.The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases.Proteolytic fragments of the N-terminal propeptide (termed CAP3,CAP5 and CAP6) are likely retained in the DISC.Cleaves and activates CASP3,CASP4,CASP6,CASP7,CASP9 and CASP10.May participate in the GZMB apoptotic pathways.Cleaves ADPRT.Hydrolyzes the small-molecule substrate,Ac-Asp-Glu-Val-Asp-|-AMC.Likely target for the cowpox virus CRMA death inhibitory protein.Isoform 5,isoform 6,isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex. |
| Uniprot ID | Q14790 |
相关搜索：Caspase 8/CASP8抗体(C-term)，Caspase 8抗体，CASP8抗体